What is the Argus Safety Database?

The Argus safety database is a key part of the Argus Safety 3.0.1 pharmacovigilance software system. In a nutshell, pharmacovigilance is defined as the monitoring of any possible adverse effects of both herbal remedies and synthetic drugs as they are used.

The digital database is used to help companies ensure compliance with global regulations regarding pharmacovigilance and related activities. As a comprehensive pharmaceutical software system, it supports pharmacovigilance business processes that take place in both the pre- and post-marketing phases.

The Argus database is hosted in a data center that is ISO-9001-certified, and operates according to the security standards promulgated by FDA guidelines. By managing this data center, a pharmaceutical firm or laboratory may obtain maximum physical data security as well as access to effective data backup and recovery procedures whenever these services are needed.

ACCOVION, the full-service contract research organization that offers pharmacovigilance as a core service, has configured the Argus database with customized and validated rules to expedite safety reporting. This setup enables generated safety reports to be sent to regulatory investigators and central ethics committees.

The system covers a wide range of the most commonly used forms, including the American FDA MedWatch 3500A form for drugs, the VAERS form for vaccines, the CIOMS-I form, and many others utilized in European countries.

The standard setup in use by the Argus safety database system includes coding with current World Health Organization and MedDRA data dictionaries, as well as older versions of these dictionaries and many others to meet user requirements.

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Who Invented Dell Computers?

The invention and the history of the Dell computer is quite interesting. First of all, it was in 1984 when Michael Dell, a student at the University of Texas at Austin, created the company PC's Limited. He only had a starting capital of $ 1,000. So what he did was started working out of his dorm room to build personal computers made from stock components. These computers were to be IBM compatible because that was the standard at that time. If a computer were to function with various pieces of hardware, it needed to be IMB compatible.

It is when Michael Dell figured that selling computers directly to customers to determine customer need that he dropped out of college. His family then extended him the $ 300,000 in expansion capital that he needed to make his business take off.

A success

It was in 1985 that the Turbo PC was developed and it sold for less than $ 800. It contained an Intel 8088 processor that ran at 8 MHz, which is significantly slower than the computers that we use today. Computers today are running in gigahertz, which are hundreds and even thousands of times faster than the 8 MHz processor that Michael Dell was installing in his computers at the time. But the truth is that this was the best that could be done in 1985. The technology was developing.

But there was an aspect of PC's Limited that was unique from the rest and continues to be this way today. It is the fact that customers could order their computers rather than buy a computer that was already assembled. This allowed individuals to receive computers at lower prices than what they could get with their competitors. This definitely worked because PC's Limited grossed $ 73 million in its first year of trading.

The beginning of Dell

It was in 1988 that PC's Limited became Dell. Prior to that, the company already had 11 international operations occurring, so the company was quite large. There were on site services set up to compensate for the lack of businesses acting as service centers for Dell computers. It was in 1990 that Dell attempted to sell through club houses, but had very little success with this. So it is then that Dell went right back to its direct to customer sales.

In 1996, Dell started selling computers on its website. An individual could go onto the website and custom design their computer so that it would be built to their specifications. From there, it would be shipped to the customer's home. Financing was made available so that individuals would be able to acquire their computers easily.

In 1999, Dell became the largest personal computer seller when they took over Compaq computers. Their revenue topped $ 25 billion in 2002. Also in 2002, Dell started selling televisions and other electronic items. They now have Dell brand printers, LCD TVs, and much more. Because of the expansion beyond computers, Dell was changed to Dell Inc. In 2003.

It is amazing that this billion dollar company started in a dorm room with $ 1000 in starting capital. And Michael Dell has always stood by the principles of letting individuals have the capability to design their own machine. Although there are Dell computers now sold in various retail outlets, a person can still go to the website and design the machine of their dreams. And Dell also offers a lot of assistance for individuals needing help with their computers. They offer on-site services and so much more for the computer user so that they can have the best experience possible.

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Benefits of an Android TV Box

The Android TV box is a useful piece of kit that connects to the TV via the HDMI port to offer most of the features of Android. This type of set up is very flexible and easily connects to most TVs with the right port and is a lot cheaper than a smart TV. Here are a few of the benefits of using the Android TV box:

Endless apps

One of the most appreciated benefits is the ability to use and install the endless apps that are now available on the Android operating system. By visiting the Google Play store using the internet connection, it is possible to install the latest apps related to not only multimedia content, but also audio editing applications, games, books, magazines, sending email, or signing into social media accounts, such as Facebook and Twitter.

TV support

By connecting the Android TV box to the TV at home via the internet; It is also possible to connect to other devices in the home, such as those that make use of technologies like Airplay, Miracast, DLNA, or others that function with Android. This makes it very flexible to share various types of multimedia with the TV. For instance, it is possible for an Android compatible tablet or smartphone to interact and control the TV while also giving the option to share files with a laptop or even watch a downloaded series or a movie on the large screen. Overall, this type of setup gives a simple gateway to get the internet on the TV.

Great price

The cost of upgrading a standard TV to benefit from all the possibilities of Android is relatively cheap compared to buying a smart TV. Plus, the combined standard TV and Android TV box can offer a lot more than a standard smart TV.

Regular updates

The Android operating system is updated on a regular basis, which means the latest version of a game, application, or system is always available. Plus, this is usually done automatically so there is no need to keep searching for updates when logged into the app store. This is significantly more convenient than a smart TV which can take a while to receive updates, especially when every brand of TV needs to have its own update created and released.

All in all, the Android TV Box makes it possible to enjoy the connectivity and versatility of Android on a standard TV set up.

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Determining the Best Type of Fastener to Use For Outdoor Furniture Construction

If you want to learn about selecting hardware for your next outdoor furniture project, then you'll want to read this article. Specifically, I'll be telling you about what type of hardware will perform best, why the type of metal used for fasteners and the finish used are important considerations, and how properly protecting or limiting exposure of your furniture to wet and winter conditions can increase Life span. After you're done with this article you will understand that the best choice of hardware for your outdoor furniture project is dependent on furniture style, material used for construction, selected location for the furniture and budget.

Selecting proper hardware for your furniture will help ensure a long life span, as well as improve the overall appearance of your furniture. Part of the problem is knowing what hardware to select when there are so many options available at the hardware store. The typical Lowes or Home Depot carries a huge selection of stainless steel, hot dipped galvanized, bright galvanized, plain steel, coated steel and brass bolts, nuts, washers and screws. Each type of fastener is suitable for certain applications, but not all are ideal for outdoor furniture applications.

In fact, choosing the wrong fasteners can greatly shorten the lifespan of your furniture, contribute to rot of wood furniture, cause unsightly staining, and even make your furniture unsafe to use.

One thing that needs to be noted right up front is, do not ever use unprotected steel fasteners for outdoor furniture, they will rust very quickly, and the steel will react with the tannic acid in the wood causing streaks and staining. The tannic acid actually speeds up the corrosion of the fasteners. Have you ever seen a wooden fence with black streaks running down the boards from the nails? This fence was installed with the wrong type of fasteners. The same thing will happen to your furniture. Even worse, as the fasteners rust, they will speed up the decay process of the wood around the rusted fasteners, ruining your furniture and making it potentially unsafe to use.

Hot Dipped Galvanized

Screws and bolts treated by hot dipped galvanizing are specifically designed for use outdoors. Electroplated galvanized or bright galvanized fasteners will very well not hold up as well as the hot dipped galvanized hardware. Zinc is used as a coating in both methods, and acts as a barrier against the elements and the tannic acids in the wood.

I strongly recommend only using screws or bolts in the construction of outdoor furniture, however. The galvanized finish on nails, either electroplated or hot dipped, can easily become damaged while hammering them in, exposing the nail head to the elements and allowing them to begin rusting quickly.

Adequate care must be taken when installing galvanized screws. Drill pilot holes in hardwoods, and be sure to use a bit that is not worn and intolerable to skipping in the screw head. For whatever reason, the galvanized screws seem to not be as well tempered as other steel fasteners, and are more likely to either snap off or have the heads strip out while installing them. Due to the permission required for the hot dipped coating, galvanized bolts do not have as tight of tolerance on the threads, and are more likely to strip if over tightened.

Hot dipped galvanized fasteners are a fine choice for many outdoor furniture applications, including Adirondack Chairs, but are not the best choice for use in woods, such as teak.

Stainless steel

Stainless steel is the best choice for use in woods with higher levels of tannic acid, such as teak. Stainless steel is an alloy or blend of steel, nickel and chrome. The ratio of the other metals with the steel determine the weather and corrosion resistance of stainless steel. Because the steel is mixed with other softer metals, the stainless steel is not as strong, so predrilling of screw holes is highly recommended in all applications, and essential in hardwoods such as teak and mahogany. The added corrosion resistance more than outweighs any shortcomings that the metal may have, especially in outdoor furniture applications.

While stainless steel fasteners are the most rust resistant, they are also the most expensive of the options we are discussing. However, using stainless steel fasteners will add years of life to your furniture. In the respect, they are an investment that will pay out for years to come.

Brass

I have seen brass used in some commercially produced outdoor furniture, but do not recommend it. While brass does not form red rust, and is well suited for many wet applications such as toilets and sinks, it does tarnish and corrode. It is also very susceptible to the tannic acids in wood, which will cause it to fail more quickly. Brass screws in particular Do not have sufficient strength for outdoor furniture applications.

Outdoor or deck screws

In the past several years a number of manufacturers have introduced outdoor fastening products specifically marketed for deck building. These will typically be green, gray, tan or brown. These screws are either ceramic or plastic coated to delay the metal reacting with the wood acids. The specific coating methods are proprietary to each manufacturer, and can be a combination of electroplated galvanizing and plastic, or a baked on ceramic.

I have used these fasteners in furniture applications and they perform just fine. Unfortunately, I have not come across bolts with this type of finish. The brand of screw I used was Deck Mate, and they were available in tan and brown, so that the color can be selected to better match the wood being used. These screws are ceramic covered, and the manufacturer provided a coated bit for installation, which was designed to not damage the ceramic coating at the screw head. If you choose this type of fastener, be sure to compare the cost with stainless steel, as the price will vary. If the stainless steel is reasonably comparable in cost, it would be the recommended fastener.

Always be sure to read the manufacturers specifications on the box to be sure that the screws are suitable for your application.

Other Considerations

If you are building furniture that will be located on a covered porch or patio where it will be protected from the elements, the concern will be the interaction between the wood and the fasteners, much more so than the weather. Furniture that will be exposed to the elements all year, such as a garden bench, or an adirondack chair in the corner of your garden, will have to be constructed with much more care and concern to ensure that they hold up more than just one or Two winters.

Additional considerations must be made beyond just the choice of what type of fastener to use, though this is very important. For example, fasteners should not be located where water where collect and sit on the fasteners for an extended period of time. The screws that attach the seat slats to an Adirondack chair are a prime example- typically these screws will be countersunk below the surface of the wood. This will allow water to collect in the screw holes, shortening the life span of all but stainless steel fasteners, and prolonging the exposure of the wood to water, which will increase the rate of decay. In applications where the furniture will be exposed to the elements year round the screw heads should be driven flush with the surface of the surrounding wood.

Construction and design of the furniture are also important considerations. Are the horizontal surfaces of the furniture constructed in such a way that will allow them to shed water, rather than collect it? Think of a picnic table with a slatted or board top. The gaps between the boards allow water a way to run off the top and not pool up.

Conclusion

Stainless steel is usually the best choice for outdoor furniture applications, although the cost may be prohibitive for some. There are other less expensive fastener options available that will perform acceptably. Do not use unprotected steel fasteners for outdoor furniture applications under any circumstances. Know where and how you intend to use your furniture and design it for the conditions it will be subjected to.

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Advantages and Disadvantages of Professional Shopping Cart Software

Advantages & Disadvantages of professional shopping cart software As e-Commerce is becoming a regular technique in the business industry it appears that more and more software development firms are developing professional shopping cart software to be released in the market. There is currently a huge range of free shopping cart software that has been released, and it seems that most e-Commerce website owners prefer these free systems over paid for professional shopping cart software. In this article we are going to look at the advantages and disadvantages of professional shopping cart software.

Advantages

• Even though you will have to pay for the solution, you get a cart package that has been fully developed, tested and used in the real working world by other e-Commerce websites. If the solution is used by a popular website service then the chances are it has been under more than enough testing to be deemed ready for use.

• Professional shopping cart software will be supported by the people who developed it. A lot of free solutions out there are simply developed and then discontinued as the freelance developers move onto their next project. Support is essential if you are going to want upgrades as mentioned in our next point.

• As the system is supported, the development team are likely to fix any bugs that may occur and provide patches and security fixes. This means the shopping cart software will only get better as time goes on and furthermore improve your e-Commerce website.

• Your site is likely to be more secure when using a professional software solution as in most cases the it developed house private content management systems. This improves security as public content management systems such as WordPress are constantly under threat from hackers as they try to compromise the free source code.

• Another huge advantage of using professionally developed software in e-Commerce is that they will already support a huge range of different payment options for your customers. There are various carts – that only offer PayPal for payment by standard, and it can take a very long time to find plug-ins or figure out how to add other methods yourself. With professional software you can save time and possibly money as it is all included.

Disadvantages

• Your e-Commerce venture might be a small time project and professional cart does cost money which you may not have. In this case you may have to make do with a free shopping cart solution. The good part of conducting business online is that after you have made profit with the free system you can reinvest your money to buy a professional package.

• You trust the developers to do everything they promise to ensure the best experience. It might be slightly difficult to use at first and you might have to spend some time getting used to the bespoke system. You also have to understand that you are vulnerable until patches are made if a security flaw is found.

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Best Windows 7 Optimizer That Can Stabilize and Improve Your Computer Performance

A system optimizer is a software designed to maintain the performance of your computer, fix software related problems and keep your computer stable and secure. The need of a system optimizer software in Microsoft Windows7 operating system is high. This is because Windows 7 itself is unable to maintain all the mentioned aspects without the help of third-party products.

We are going to learn what exactly Windows 7 optimizer software is.

The best Windows 7 optimizer software shall include all the following features:

1. Registry Cleaner to fix the registry related issues

2. System Cleaner to clean unnecessary stuff and free-up the disk space

3. Registry Defragmenter to defrag the system registry

4. Startup Manager to control the programs running when you turn on your computer

5. Backup & Restore feature to restore unfavourable registry changes

“Registry Cleaner” to Fix the Registry Related Issues

Windows Registry is a vital component in Microsoft Windows 7. It contains information stored by your operating system and installed software. For example, the default settings, changes you made to your computer, system information, runtime data, etc. are stored.

Registry Cleaner is a software that finds the junk entries in the registry, and repairs them as far as possible. Unfortunately, Windows 7 does not include a built-in registry cleaner. The registry cleaner software included in the best Windows 7 optimizer lets you scan the genuine registry problems and correct them. It thereby helps avoiding many runtime errors and problems, such as, File Not Found, etc.

“System Cleaner” to Clean Unnecessary Stuff and Free-Up the Disk Space

A System Cleaner software lets you find the files and stuff that have unnecessarily occupied the hard disk space.

The tasks, like installing a program, uninstalling, repairing or updating the existing programs, and even just running the installed programs many times create temporary files, log files that need not be kept after the corresponding operation is performed. Sadly, many programs do not itself delete such files and stuff and thus your hard disk space is used for such unproductive stuff. Using a system cleaner software included in best Windows 7 optimizer, you can easily and safely delete such temporary stuff.

“Registry Defragmenter” to Defrag the System Registry

You know the importance of the registry in Windows 7 operating system, as already discussed. The continuous access of a number of programs to the registry results in its fragmentation. It reduces the system performance and freezes your computer.

The best Windows 7 optimizer software includes a registry defragmenter that enables analyzing the registry fragmentation and afterwards defrags it. A reboot is required to perform this process and all other running programs and services must be terminated.

“Startup Manager” to Control the Programs when you Turn on your Computer

Running too many programs at the Windows startup, results in system freezing and slow performance. A Startup Manager, included in best Windows 7 optimizer, lets you monitor and control the programs that run each time your computer is started. It lets you disable or delete the unwanted program entries and enable only those who are necessary.

Backup & Restore Feature to Restore the Unfavourable Registry

While doing all the above steps, care must be taken that you have followed some precautionary measures first, so that any unfavourable registry change can be later restored and unwilling situations can be easily avoided. The best Windows 7 optimizer should include such a feature.

Best Windows 7 Optimizer Recommended by Worldwide Experts

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The Leading Gaming PC Cases Are Essential To Help Protect and Power Your Extreme Gaming Hardware

Gaming PC Cases come in a variety of shapes and sizes. From rack mount to ATX tower casing, you can find one that best suits your gaming needs. Many games are played by as many 15-24 users and such games require the power of hardware to control both the graphics and many millions of instructions to the CPU with great speed. Custom Gaming PCs are the current rave with game lovers who strive for a better playing experience, adding more hardware.

With a large variety of casing, it is confusing to choose the right one. A good PC Case for gaming is one that has ample space to add more fans and USB ports. Heating is the main problem that slows down the PC and in some instances can damage it. Looks also matter a lot, an attractive and next-gen look, makes for a better playing experience.

All gaming PC cases come with microphones and headphone sockets, while the more advanced ones have fan controllers. New game players can do with two fans while some want to get additional fans to keep the PC from heating up. More advanced users utilize much of CPU power, and need more cooling.

When you are ready to buy a case, first look at the price options, compare various makes and models and see where you can save money and get the same functionality. The most accommodating case is considered the best. It will allow for more fans, and offers ample space for advanced graphic cards. Check to see, if the case can allow more than 4 fans and has at least two USB ports.

Some cases come with 4 USB ports and have space for up to six fans. If you are an advanced level player, you may want to consider one that has a fan speed controller, so you can monitor the cooling easily. Further up the ladder, there are cases that come with space for as many as 12 hard drives. Such a case, can take any kind of mother board you want to use.

The ATX are more popular these days and are like the industry standard. ATX form-factor allows for better air passage so all components can stay cool. It uses less cable, generates less heat and is more affordable. The expansion slots are easily accessible making it easy for users to add more graphic cards.

Looks wise, a clear panel looks attractive and spices up the computer using LEDs. There are also cases with bright graphics, and a modish look to add to the adventure. It all depends on your game choice, if you like a good thrill considering Gaming PC Cases that will add excitement to game time.

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What Is The Difference Between ERP And Enterprise System?

Enterprise system and Enterprise Resource Planning System terms are similar but there is difference between an enterprise system and an ERP system. An ES or enterprise system is a large scale system which includes packages like ERP and CRM. ERP is a subset of Enterprise System or it can be said that ES is a superset of ERP. It contains a variety of solutions. ES contains applications and packaged solutions which can be directly used in an enterprise. On the other hand ERP system is the automation of the business processes and the solutions are in the form of modules which are designed according to the client’s requirements.

The functions are customized according to the client’s business environment. Enterprise system does not include architecture of other solutions whereas an ERP implementation automates systems using technical aspects. ERP system includes architectures and databases and is client server architecture. The system is server based therefore the consultant needs to be aware of the technical aspect too.

Another difference between an ES and an ERP system is that the ERP is aimed at improving the functionalities of the organization whereas the ES helps to improve the overall maintenance and accuracy. It provides for better solutions and aids in decision making. ES is difficult to implement compared to Enterprise resource planning and even the timeframe needed for implementation maybe more. The overall impact is high but so are the risks involved. If the ES is not implemented in the right manner, it can cause business failure and if implemented properly it can increase the efficiency and profits of the business organization. It is normally required when there is a big drawback in the current procedures and methodologies in the organization and need to be corrected. The company going in for enterprise system needs to be careful while choosing the software and the vendors due to the risk of failure involved.

The difference between an enterprise system and an ERP system is that ERP is mostly used for medium scale companies to big companies and ES is restricted to the big companies. There are many complex functions involved in big companies which cannot be provided solutions for alone by ERP. The role of ERP is restricted when compared to enterprise system because it does not include customer relationship or vendor management.

These applications are needed when the business process is complex and on a big scale. Therefore bigger organizations need to go with ES instead of enterprise resource planning alone. ERP is also an important system to streamline the internal processes but it does not provide for taking care of the external processes. Enterprise system takes care of the end to end business process of organization since it involves other applications also like SCM and CRM. There is quite a lot of difference between an enterprise system and an ERP and it depends on the company whether it wants to go with an ES to streamline the entire process starting from supplying, production and customer or whether he wants to go with an ERP system to streamline the internal process.

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Jingle Maker – Making Jingles With Desktop Music Maker Software

Looking to get into the jingle maker industry? It’s not exactly an easy field to break into but it is worth the trouble if you are ready to put forth the necessary time and effort to make it. If you are not already a professional musician then you will need a way to produce your jingles. We recommend desktop music maker software for this purpose. The rest of this article will cover the top three things you should look for when it comes to a desktop music making application for making jingles.

Feature #1 – Professional Music Production

If you are approaching the jingle making from the perspective of making money then you need to make sure your entire production is created in the manner that lends itself for commercial adaptation. This is essential if you expect your jingles to be used as radio jingles, commercial jingles or advertising jingles. For starters that means making sure you are able to create music output that is a minimum of 44,1 khz.wav files. You will also want to be able to create real bars of music versus samples or loops. This is a benefit of using music making software because it will make sure your music is created to be communicated to other musicians for playback.

Feature #2 – Variety Of Features

When you are just get started you will want something that allows you to take the melodies in your head and get them into music as quick as possible. Yet at the same time you don’t want to have to learn another application as your own skill set grows. This is why it makes sense to choose software that is usable as a beginner and expert alike. It should come with a number of presets that you can expand upon and purchase as your own abilities grow.

Feature #3 – Complete With Sound Generator

You never know where your jingle making skills will take you so you should also have access to making sound effects. It’s not necessarily a must have feature but if you have the choice then make it for software that does include this. You just never know when you may need this as a jingle maker.

We have briefly looked at some of the features you may want to look for when searching for music maker software for your jingle production exercise. The needed feature set should include professional music production capabilities, a variety of features and a sound generator. Of course these are just a small sample of features that you will find when looking for music maker software. But having the right tools just means you will be that much closer to creating the next set of catchy jingles.

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Advantages and Disadvantages of Professional Shopping Cart Software

Advantages & Disadvantages of professional shopping cart software As e-Commerce is becoming a regular technique in the business industry it appears that more and more software development firms are developing professional shopping cart software to be released in the market. There is currently a huge range of free shopping cart software that has been released, and it seems that most e-Commerce website owners prefer these free systems over paid for professional shopping cart software. In this article we are going to look at the advantages and disadvantages of professional shopping cart software.

Advantages

• Even though you will have to pay for the solution, you get a cart package that has been fully developed, tested and used in the real working world by other e-Commerce websites. If the solution is used by a popular website service then the chances are it has been under more than enough testing to be deemed ready for use.

• Professional shopping cart software will be supported by the people who developed it. A lot of free solutions out there are simply developed and then discontinued as the freelance developers move onto their next project. Support is essential if you are going to want upgrades as mentioned in our next point.

• As the system is supported, the development team are likely to fix any bugs that may occur and provide patches and security fixes. This means the shopping cart software will only get better as time goes on and furthermore improve your e-Commerce website.

• Your site is likely to be more secure when using a professional software solution as in most cases the it developed house private content management systems. This improves security as public content management systems such as WordPress are constantly under threat from hackers as they try to compromise the free source code.

• Another huge advantage of using professionally developed software in e-Commerce is that they will already support a huge range of different payment options for your customers. There are various carts – that only offer PayPal for payment by standard, and it can take a very long time to find plug-ins or figure out how to add other methods yourself. With professional software you can save time and possibly money as it is all included.

Disadvantages

• Your e-Commerce venture might be a small time project and professional cart does cost money which you may not have. In this case you may have to make do with a free shopping cart solution. The good part of conducting business online is that after you have made profit with the free system you can reinvest your money to buy a professional package.

• You trust the developers to do everything they promise to ensure the best experience. It might be slightly difficult to use at first and you might have to spend some time getting used to the bespoke system. You also have to understand that you are vulnerable until patches are made if a security flaw is found.

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